Cesium carbonate → HCID 68000648, compound

Participants

Reaction Steps

The process is performed according to the procedure described in Example 2 (step 2.7.). Starting with 1.00 g (2.09 mmol) of ethyl 5-[6-(5-bromopyridin-2-yl)-6-azaspiro[3.4]oct-2-ylcarbamoyloxymethyl]isoxazole-3-carboxylate (isomer 6) and 0.29 g (2.09 mmol) of 4-fluorophenylboronic acid, 2.03 g (6.26 mmol) of caesium carbonate and 0.17 g (0.21 mmol) of PdCl2dppf.CH2Cl2, 0.50 g of a gum is obtained after chromatography on silica gel, eluting with a 90/10 mixture of cyclohexane and ethyl acetate.

Provenance & Evidence