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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 336612Generated: October 30, 2026

Amantadine → 3-bromo-N,2-dimethyl-N-(tricyclo[3.3.1.13,7]dec-2-yl)benzamide

https://huagongshe.com/reaction/336612

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmantadineHCID 2130—
Reactant1-Adamantanecarbonyl chlorideHCID 98915—
Reactant3-Bromo-2-methylbenzoyl chlorideHCID 19367807—
Product3-bromo-N,2-dimethyl-N-(tricyclo[3.3.1.13,7]dec-2-yl)benzamideHCID 89498641—

Reaction Steps

The title compound was prepared by substituting N-adamantan-2-yl-N-methyl-amine for 1-adamantanamine and 3-bromo-2-methylbenzoyl chloride for 1-adamantanecarbonyl chloride in EXAMPLE 50A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889675B2
Source datasetuspto-grants-2014_11
ORD IDord-696e6b4402984b058db85639d3173f03
Source noteuspto-grants-2014_11