Tricyclo(3.3.1.1'3,7)dec-1-ylmethanol → HCID 86681273, compound

HRID 336616Notes

Reaction equation

HRID 336616 reaction equation
[C:1]12([CH2:11]O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)C1)[CH2:8]2.[C:13]([C:15]1[NH:16][C:17]([CH3:20])=[CH:18][CH:19]=1)#[N:14].CC1C(B2OC(C)(C)C(C)(C)[O:28]2)=C(C)NN=1>>[CH3:20][C:17]1[N:16]([CH2:11][C:1]23[CH2:8][CH:7]4[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]4)[O:28]2)[CH2:10]3)[C:15]([C:13]#[N:14])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 64556Tricyclo(3.3.1.1'3,7)dec-1-ylmethanolHCID 5706055-Methyl-1H-pyrrole-2-carbonitrileHCID 162177133,5-Dimethylpyrazole-4-boronic acid, pinacol ester

Product 1

HCID 86681273HCID 86681273, compound

Procedure

The title compound was prepared by substituting 1-hydroxymethyl-2-oxadamantane for 1-adamantanemethanol and 2-cyano-5-methylpyrrole for 3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole in EXAMPLE 2A.

Sources & evidence

ORD record
ord-af89f751770f465b8f4b60130950e55a
Source dataset
uspto-grants-2014_11
Patent number
US08889675B2

Reaction notes

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