反应详情

To a solution of EXAMPLE 81A (300 mg) in methanol (2 mL) was added sodium methoxide (4 mL, 0.5 M in methanol). Iodomethane (0.5 mL) was added, and the reaction heated to reflux for 3 hours. The reaction was cooled to room temperature and concentrated to dryness. The residue war purified by reverse phase HPLC, eluting with a gradient of 30% to 100% acetonitrile in water containing 0.1% v/v trifluoroacetic acid, to give the title product.

1. temperaturethe reaction heated
2. temperatureto reflux for 3 hours
3. concentrationconcentrated to dryness
4. customThe residue war purified by reverse phase HPLC
5. washeluting with a gradient of 30% to 100% acetonitrile in water containing 0.1% v/v trifluoroacetic acid