HRID336674

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)c1cc(C=O)cc(C(C)(C)C)c1O

HCID73219

3,5-Di-tert-butyl-4-hydroxybenzaldehyde

C15H22O2

HCID20349016

2-Amino-4,6-dimethoxybenzamide

C9H12N2O3

反应SMILES：COc1cc(OC)c2c(=O)[nH]c(-c3ccccn3)nc2c1

HCID136037998

未命名化合物

PRODUCTS

产物

反应SMILES：COc1cc(OC)c2c(=O)[nH]c(-c3cc(C(C)(C)C)c(O)c(C(C)(C)C)c3)nc2c1

HCID136037991

未命名化合物

收率 41%

PROCEDURE

实验过程

2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 3,5-di-tert-butyl-4-hydroxybenzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (130 mg, 41%) was isolated as a light yellow solid. Selected data: MS (m/z): 411.17; MP 229.7-230.5° C.