Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 336675Generated: October 30, 2026

3,5-Dimethoxybenzaldehyde → 2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

https://huagongshe.com/reaction/336675

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,5-DimethoxybenzaldehydeHCID 81747—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-oneHCID 13590786546%

Reaction Steps

2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 3,5-dimethoxybenzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(3,5-dimethoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (120 mg, 46%) was isolated as a yellow solid. Selected data: MS (m/z): 343.05; MP 270-272° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889698B2
Source datasetuspto-grants-2014_11
ORD IDord-fe0f1e131aee4e3fa051cc1d4dad0503
Source noteuspto-grants-2014_11