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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 336677Generated: October 30, 2026

Vanillin → 2-(4-Hydroxy-3-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

https://huagongshe.com/reaction/336677

Reaction equation

Participants

RoleNameHCIDCharge
ReactantVanillinHCID 1183—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product2-(4-Hydroxy-3-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-oneHCID 13603799336%

Reaction Steps

2-(4-Hydroxy-3-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 4-hydroxy-3-methoxybenzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(4-Hydroxy-3-methoxyphenyl)-5,7-dimethoxyquinazolin-4(3H)-one (90 mg, 36%) was isolated as a white solid. Selected data: MS (m/z): 329.06; MP 294-296° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889698B2
Source datasetuspto-grants-2014_11
ORD IDord-4fce3546766b44d79e3e6586aac96ed2
Source noteuspto-grants-2014_11