tert-butyl 5-nitro-1H-pyrazol-3-ylcarbamate → tert-butyl N-(5-amino-1H-pyrazol-3-yl)carbamate

Participants

Reaction Steps

To 5.88 g (25.77 mmol) of tert-butyl 5-nitro-1H-pyrazol-3-ylcarbamate diluted in 145 ml of methanol, are added under inert atmosphere 600 mg of palladium on charcoal (10%), then the reaction mixture is stirred under hydrogen atmosphere for 24 h. The solution is filtered on Celite and rinsed with ethyl acetate. The filtrate is concentrated to yield 4.93 g of tert-butyl 5-amino-1H-pyrazol-3-ylcarbamate in the form of a grey solid.

Provenance & Evidence