反应详情

6.40 g (32.00 mmol) of N-methoxy-N-methyl-5-nitro-1H-pyrazole-3-carboxamide are dissolved in 500 ml of tetrahydrofuran/methanol mixture (50:50). The solution is purged under argon and 220 mg of palladium on charcoal (10%) are added. The solution is then degassed with hydrogen and stirred under a hydrogen atmosphere for 18 h. After degassing with argon, the solution is filtered on Celite and the solvent is concentrated to yield 5.2 g of 5-amino-N-methoxy-N-methyl-1H-pyrazole-3-carboxamide in the form of a white solid.

1. customThe solution is purged under argon
2. addition220 mg of palladium on charcoal (10%) are added
3. customThe solution is then degassed with hydrogen
4. customAfter degassing with argon
5. filtrationthe solution is filtered on Celite
6. concentrationthe solvent is concentrated