Hydrochloric Acid → HCID 67074198, compound

Participants

Reaction Steps

A solution of 0.10 g (0.32 mmol) of 6-(4-cyanophenyl)-4-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile and 0.22 g (4.0 mmol) of potassium hydroxide in a mixture of 2 ml of dioxane, 2 ml of MeOH, and 0.75 ml of water is refluxed for 24 h. Next, the mixture is cooled, acidified with 1N HCl, then extracted with ethyl acetate and dichloromethane. The organic phase is dried over sodium sulfate, filtered and concentrated to give 0.018 g (17%) of 4-(5-cyano-4-(furan-2-yl)-1H-pyrazolo[3,4-b]pyridine-6-yl)benzoic acid in the form of brown crystals.

Provenance & Evidence