Ethyl bromopyruvate → HCID 136414064, compound

Participants

Reaction Steps

To 66 mg (0.20 mmol) of N-(5-cyano-6-(2-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-3-yl)carbamimidothioic acid diluted in 2 ml of ethanol are added 57 mg (0.20 mmol, 68%) of ethyl 3-bromo-2-oxopropanoate. The solution is refluxed for 2 h. The solid is filtered, washed with ethanol and dried to give 38 mg of ethyl 2-(5-cyano-6-(2-fluoro-4-hydroxyphenyl)-1H-pyrazolo[3,4-b]pyridine-3-ylamino)thiazole-4-carboxylate in the form of a yellow solid.

Provenance & Evidence