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Acetic Acid → 3-Chloropropyl 4-(piperidinomethyl)phenyl ether
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 4-(3-Chloropropoxy)-benzaldehyde | HCID 3551479 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Chloropropyl 4-(piperidinomethyl)phenyl ether | HCID 4365932 | — |
反応手順
A solution of the product of Example 11 (5.0 g), piperidine (3.1 mL), and acetic acid (2.0 mL) in DCE (100 mL) was treated with sodium triacetoxyborohydride (9.3 g). After 16 h, the resulting mixture was diluted with water (100 mL) and extracted with DCM (3×50 mL). The combined organic phases were dried (magnesium sulfate) and evaporated, giving the title compound as an amber oil (5.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07429586B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-0f6a1b78e90f4fbab30ad09c9eb5890a |
| 出典メモ | uspto-grants-2008_09 |