反应详情

温度

20 °C

A solution of α,α-dimethyl-2-(phenylmethoxy)-benzeneacetamide (Example 198c, 19.45 g) dissolved in acetonitrile (200 mL) and water (200 mL) was treated with (Bis(trifluoroacetoxy)iodo)benzene (31.1 g) under nitrogen. The resulting solution was stirred at 20° C. for 60 h. The reaction mixture was diluted with water (300 mL), and extracted with diethyl ether. The aqueous layer was basified at 0° C. with 2M NaOH solution and extracted with ethyl acetate. The organic was dried (MgSO4), filtered and evaporated to afford the subtitle compound (13.26 g).

1. extractionextracted with diethyl ether
2. customwas basified at 0° C. with 2M NaOH solution
3. extractionextracted with ethyl acetate
4. dry with materialThe organic was dried (MgSO4)
5. filtrationfiltered
6. customevaporated