Potassium Nitrate → 2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid

HRID 337081Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 337081
[Cl:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[N+:13]([O-])([O-:15])=[O:14].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[C:10]([N+:13]([O-:15])=[O:14])=[C:9]([CH3:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Komponenten

4

Edukt 2

HCID 24434Potassium NitrateHCID 136574382-Chloro-5-fluoro-4-methylbenzoic acid

Produkt 1

HCID 136574392-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acidAusbeute 102,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1118Sulfuric AcidLösungsmittel

Versuchsvorschrift

A solution of 2-chloro-5-fluoro-4-methylbenzoic acid (Example 252b, 51.57 g) dissolved in conc sulfuric acid (143 mL) was treated with potassium nitrate (32.4 g) portionwise over 10 min at 0° C. under nitrogen. The resulting mixture was allowed to warm to room temperature before stirring at 50° C. for 1 h. The reaction mixture was quenched with ice water and the precipitate was collected and dried in vacuo to afford the subtitle compound (65.5 g).

Aufarbeitung

  1. customThe reaction mixture was quenched with ice water
  2. customthe precipitate was collected
  3. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a364cae30ff64feab44a58777c762c5f
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08889692B2

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