Ammonia → HCID 86663250, compound

HRID 337096Notes

Reaction equation

HRID 337096 reaction equation
[NH3:1].[CH2:2]([C:4]1([CH2:14][CH3:15])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[O:6][C:5]1=[O:13])[CH3:3]>CO.O>[CH2:2]([C:4]([CH2:14][CH3:15])([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=1[OH:6])[C:5]([NH2:1])=[O:13])[CH3:3]

Participants

5

Reactant 2

HCID 222Ammonia2×HCID 66689272HCID 66689272, compound

Product 1

HCID 86663250HCID 86663250, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

7N Ammonia in methanol (10 mL) was added to 3,3-diethyl-2(3H)-benzofuranone (Example 266a, 1.14 g) and the reaction stirred at room temperature for 16 h. 880 Ammonia (20 mL) was added and the mixture stirred for 5 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried (MgSO4), filtered and evaporated to afford crude product (1.21 g).

Workup

  1. stirringthe mixture stirred for 5 h
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried (MgSO4)
  4. filtrationfiltered
  5. customevaporated

Sources & evidence

ORD record
ord-94444d3f9af5494cbe53beac74081d5e
Source dataset
uspto-grants-2014_11
Patent number
US08889692B2

Reaction notes

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