Ethylamine → HCID 66688814, compound

HRID 337100Notes

Reaction equation

HRID 337100 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:16][C:17]1[C:18](=[O:36])[N:19]([C:23]2[CH:24]=[C:25]([CH:32]=[CH:33][C:34]=2[CH3:35])[C:26]([NH:28][CH:29]2[CH2:31][CH2:30]2)=[O:27])[CH:20]=[CH:21][N:22]=1)([CH2:14][CH3:15])[CH2:12][CH3:13].[CH2:37]([NH2:39])[CH3:38]>O>[CH:29]1([NH:28][C:26](=[O:27])[C:25]2[CH:32]=[CH:33][C:34]([CH3:35])=[C:23]([N:19]3[CH:20]=[CH:21][N:22]=[C:17]([NH:16][C:11]([CH2:14][CH3:15])([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH2:3][CH2:2][NH:39][CH2:37][CH3:38])[CH2:12][CH3:13])[C:18]3=[O:36])[CH:24]=2)[CH2:31][CH2:30]1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 66689398HCID 66689398, compound

Product 1

HCID 66688814HCID 66688814, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared from 3-[3-[[1-[2-(2-chloroethoxy)phenyl]-1-ethylpropyl]amino]-2-oxo-1(2H)-pyrazinyl]-N-cyclopropyl-4-methyl-benzamide (Example 266e) using the method described in Example 167f but using 70% ethylamine in water.

Sources & evidence

ORD record
ord-eefdbe0f70374289a1c65ad5f4ee91f0
Source dataset
uspto-grants-2014_11
Patent number
US08889692B2

Reaction notes

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