HRID337118

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID66688931

未命名化合物

结构：COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(Br)c2=O)c1

HCID66689945

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cc(F)c(C)c(-n2cc(Br)nc(NC3(c4cc(F)ccc4OCc4ccccc4)CC3)c2=O)c1

HCID66689772

未命名化合物

PROCEDURE

实验过程

The subtitle compound was prepared from 1-(2-(benzyloxy)-5-fluorophenyl)cyclopropanamine (Example 278a) and methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-5-fluoro-4-methylbenzoate (Example 252g) using a similar method to that described for Example 268d.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ab57fb7b4094a318e3580e392ae75b5
来源数据集: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08889692B2
来源说明: uspto-grants-2014_11

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[C:16]1([NH2:19])[CH2:18][CH2:17]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:21]1[C:22](=[O:40])[N:23]([C:28]2[CH:29]=[C:30]([CH:35]=[C:36]([F:39])[C:37]=2[CH3:38])[C:31]([O:33][CH3:34])=[O:32])[CH:24]=[C:25]([Br:27])[N:26]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[C:16]1([NH:19][C:21]2[C:22](=[O:40])[N:23]([C:28]3[CH:29]=[C:30]([CH:35]=[C:36]([F:39])[C:37]=3[CH3:38])[C:31]([O:33][CH3:34])=[O:32])[CH:24]=[C:25]([Br:27])[N:26]=2)[CH2:18][CH2:17]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1