Ethanolamine → HCID 66689755, compound

HRID 337119Notes

Reaction equation

Cl[CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][C:6]=1[C:12]1([NH:15][C:16]2[C:17](=[O:36])[N:18]([C:22]3[CH:23]=[C:24]([CH:31]=[C:32]([F:35])[C:33]=3[CH3:34])[C:25]([NH:27][CH:28]3[CH2:30][CH2:29]3)=[O:26])[CH:19]=[CH:20][N:21]=2)[CH2:14][CH2:13]1.[CH2:37]([CH2:39][NH2:40])[OH:38]>>[CH:28]1([NH:27][C:25](=[O:26])[C:24]2[CH:23]=[C:22]([N:18]3[CH:19]=[CH:20][N:21]=[C:16]([NH:15][C:12]4([C:6]5[CH:7]=[C:8]([F:11])[CH:9]=[CH:10][C:5]=5[O:4][CH2:3][CH2:2][NH:40][CH2:39][CH2:37][OH:38])[CH2:14][CH2:13]4)[C:17]3=[O:36])[C:33]([CH3:34])=[C:32]([F:35])[CH:31]=2)[CH2:30][CH2:29]1

Participants

Reactant 2

HCID 700Ethanolamine

HCID 66688599HCID 66688599, compound

Product 1

HCID 66689755HCID 66689755, compound

Procedure

The title compound was prepared from 3-[3-({1-[2-(2-chloroethoxy)-5-fluorophenyl]cyclopropyl}amino)-2-oxopyrazin-1(2H)-yl]-N-cyclopropyl-5-fluoro-4-methylbenzamide (Example 281c) and ethanolamine using a similar method to that described for Example 167f.

Sources & evidence

ORD record: ord-510f7e74702642229dcda6b9b79014cc
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889692B2

Reaction notes

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