Methyl 2-bromopropionate → HCID 66689622, compound

HRID 337135Notes

Reaction equation

HRID 337135 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:14][C:15]1[C:16](=[O:35])[N:17]([C:21]2[CH:22]=[C:23]([CH:30]=[C:31]([F:34])[C:32]=2[CH3:33])[C:24]([NH:26][CH:27]2[CH2:29][CH2:28]2)=[O:25])[CH:18]=[CH:19][N:20]=1)([CH3:13])[CH3:12].Br[CH:37]([CH3:42])[C:38]([O:40]C)=[O:39]>>[CH:27]1([NH:26][C:24]([C:23]2[CH:30]=[C:31]([F:34])[C:32]([CH3:33])=[C:21]([N:17]3[CH:18]=[CH:19][N:20]=[C:15]([NH:14][C:11]([C:6]4[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=4[O:4][CH2:3][CH2:2][NH:1][CH2:42][CH2:37][C:38]([OH:40])=[O:39])([CH3:12])[CH3:13])[C:16]3=[O:35])[CH:22]=2)=[O:25])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 95576Methyl 2-bromopropionateHCID 25143767HCID 25143767, compound

Product 1

HCID 66689622HCID 66689622, compound

Procedure

of the title compound was prepared from 3-(3-(2-(2-(2-aminoethoxy)phenyl)propan-2-ylamino)-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-5-fluoro-4-methylbenzamide (Example 311) and methyl bromopropanoate using a similar method to that described for Example 312.

Sources & evidence

ORD record
ord-6faafd5db8f04ba8bac51d4275a4bc9a
Source dataset
uspto-grants-2014_11
Patent number
US08889692B2

Reaction notes

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