참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 2-[3-(1-Piperidinyl)propoxy]benzaldehyde | HCID 13795259 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | [2-(3-Piperidin-1-yl-propoxy)-benzyl]-pyridin-2-yl-amine | HCID 17962598 | — |
| 생성물 | Ammonia dichloromethane | HCID 22731429 | 1% |
반응 단계
A solution of 2-(3-piperidin-1-yl-propoxy)-benzaldehyde (269 mg), 2-aminopyridine (110 mg), and acetic acid (0.07 mL) in DCM (5 mL) was treated with sodium triacetoxyborohydride (410 mg). After 16 h, the resulting mixture was treated with 10% sodium hydroxide (6 mL) and extracted with DCM (3×10 mL). The combined organic phases were dried (sodium sulfate) and evaporated. Chromatography of the residue (1-5% 2 M methanolic ammonia/DCM) gave the title compound as a colorless oil (128 mg). 1H NMR (400 MHz, CDCl3): 8.07 (m, 1H), 7.37 (m, 1H), 7.29 (m, 1H), 7.22 (m, 1H), 6.91-6.84 (m, 2H), 6.54 (m, 1H), 6.37 (m, 1H), 5.00 (m, 1H), 4.48 (d, J=5.6, 2H), 4.04 (t, J=6.3 Hz, 2H), 2.52 (m, 2H), 2.41 (br, 4H), 2.02.(m, 2H), 1.64-1.57 (m, 4H), 1.47-1.40 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07429586B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_09 |
|---|
| ORD ID | ord-642ff68e1d5049d087b71007bf74e71c |
|---|
| 출처 메모 | uspto-grants-2008_09 |
|---|
