Sodium Hydroxide → HCID 44819462, compound

Participants

Reaction Steps

A sealed tube was charged with (N-[(1R,2S,3R)-2,3-dihydroxycyclohexyl]-3-[(2-fluoro-4-iodophenyl)amino]isonicotinamide) (8) (42 mg, 0.09 mmol), Sodium borohydride (34 mg, 0.89 mmol), palladium dichloride (7.9 mg, 0.04 mmol), sodium hydroxide (17.8 mg, 0.45 mmol), THF-Water (1:1, 3 ml). The mixture was stirred at room temperature for 2 days. The mixture was filtered and the filtrate was concentrated. The resulting residue was subjected to flash chromatography to obtain the product. LC/MS [Method A: rt: 0.43 min; m/z: 346 (M+1)].

Provenance & Evidence