反应详情

[(1-{4-[Methyl-(tetrahydro-pyran-4-carbonyl)-amino]-benzenesulfonyl}-piperidin-4-yl)-carbamic acid tert-butyl ester (0.17 g, 0.4 mmol) was suspended in a 4M solution of HCl in Dioxane (5 ml). The resulting suspension was stirred at room temperature for 3 hours. After this time the solution was concentrated under vacuum, then azeotroped with methanol and suspended in diethyl ether. The resulting solid precipitate was then collected by filtration, washed with diethyl ether and dried under vacuum to afford the title compound (0.17 g, Quantitative yield) as a white solid. Tr=1.20 min, m/z (ES+) (M+H)+ 382.

1. concentrationAfter this time the solution was concentrated under vacuum
2. customazeotroped with methanol
3. filtrationThe resulting solid precipitate was then collected by filtration
4. washwashed with diethyl ether
5. customdried under vacuum