Potassium Bicarbonate → HCID 71060086, compound

Participants

Reaction Conditions

Reaction Steps

Methanesulfonic acid 4-benzyloxycarbonylamino-benzyl ester (0.35 g, 2.5 mmol) was added to a suspension of piperidin-4-yl-carbamic acid tert-butyl ester (0.15 g, 0.76 mmol) and potassium bicarbonate (0.35 g, 2.5 mmol) in DMF (10 ml) and the reaction heated to 60° C. and stirred at this temperature for 16 hours under a nitrogen atmosphere. After this time, the reaction mixture was cooled to room temperature and the solvent removed. The resulting residue was diluted with EtOAc (50 ml) and washed with water (10 ml). The organic layer was separated, dried (MgSO4), filtered and concentrated and the resulting residue was triturated with EtOAc, the resulting precipitate collected by filtration and dried under vacuum to give the title compound (0.14 g, 37% yield) as a white solid. Tr=1.58 min, m/z (ES+) (M+H)+ 440.

Provenance & Evidence