HCID 71258011, compound → HCID 71257872, compound

Participants

Reaction Steps

To a solution of N,4-di-tert-butyl-2-fluoro-6-(hydroxymethyl)benzamide (4.3 g, 15.3 mmol, Eq: 1.00) in MeOH (100 ml) was added Pd—C 10% (50% wet) (1.19 g) and the reaction mixture was stirred under H2 atmosphere (balloon) for 3 h. Reaction mixture was filtered over a celite pad and the celite pad washed with EtOH(3×50 mL). The combined filtrate and washes were evaporated under vacuum to give 4.01 g of product as a white solid (99% yield); LC/MS, m/z 266[M+H]+. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 1.30 (s, 9 H) 1.48 (s, 9 H) 2.41 (s, 3 H) 5.60 (br. s., 2 H) 6.90-6.95 (m, 1 H) 7.00 (d, J=0.51 Hz, 1 H).

Provenance & Evidence