Water → HCID 60143708, compound

Participants

Reaction Steps

118.4 mg of 1-(2,4-dimethoxyphenyl)-3,5-dimethyl-1H-pyrazol was dissolved in 2.3 ml of methylene chloride, and 1.7 ml of 1M solution of boron tribromide in methylene chloride was added at room temperature and stirred for 1 hour. The reaction mixture was added to 30 ml of water, neutralized with 1N-sodium hydroxide, and extracted with 50 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and purified using preparative thin-layer silica gel column chromatography (hexane:ethyl acetate=1:2) to yield 71.7 mg of the title compound.

Provenance & Evidence