Water → HCID 11265881, compound

Participants

Reaction Steps

400 mg of 2-amino-5-methylphenol was dissolved in 6.5 ml of dichloromethane, and 476 μl of triethylamine and 619 mg of p-toluene sulfonylchloride were added and stirred at room temperature for 1 hour. To the reaction mixture, 60 ml of water was added, and extracted with 60 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure, and purified using silica gel column chromatography (hexane:ethyl acetate=3:1) to yield 730.1 mg of the title compound.

Provenance & Evidence