Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → p-(Triethylsilyl)ethynyl phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4-Iodophenol | HCID 10894 | — |
| 반응물 | (Triethylsilyl)acetylene | HCID 637947 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | p-(Triethylsilyl)ethynyl phenol | HCID 22644432 | — |
반응 단계
Triethylsilylacetylene 108 (3 eq.) was coupled to 4-iodophenol 107 (1 eq.) in the presence of CuI (0.05 eq.), Pd[PPh3]4 (0.05 eq.), and triethylamine (2 eq.) in DMF. The mixture was stirred at ambient temperature for 5 hours after which it was concentrated under vacuum to afford a crude black oil. The oil was purified by flash column chromatography to afford pure p-(triethylsilyl)ethynyl phenol 109.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07429651B2 |
| 출처 데이터셋 | uspto-grants-2008_09 |
| ORD ID | ord-09850c3b7c7744fb8d0d7d1ff3e4dbe5 |
| 출처 메모 | uspto-grants-2008_09 |