反应详情

温度

40 °C

2,5-dimethoxy toluene (6.0 g) was dissolved in acetic acid (20 mL). To the solution, a solution of fuming nitric acid (d=1.50, 4.32 g) in acetic acid (10 mL) was added dropwise at 40° C. over a period of 5 min. The mixture was stirred at 40° C. for 30 min. The reaction mixture was then allowed to cool to room temperature, which was stirred for another 30 min. Then the reaction mixture was diluted with cold water (300 mL). The resulting precipitate was filtered washed with cold water (100 mL) and dried under reduced pressure to afford the title compound (7.5 g).

1. temperatureto cool to room temperature
2. stirringwhich was stirred for another 30 min
3. filtrationThe resulting precipitate was filtered
4. washwashed with cold water (100 mL)
5. customdried under reduced pressure