1-[5-(2,3-Dihydro-benzofuran-5-yl)-4-methoxythiophen-3-yl]ethanone → 1-[5-(2,3-Dihydro-benzofuran-5-yl)-4-hydroxythiophen-3-yl]ethanone

HRID 337376Notes

Reaction equation

HRID 337376 reaction equation
OC1C(C(=O)C)=CSC=1C1C=CC2CCCCC=2C=1.[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([C:29]3[S:33][CH:32]=[C:31]([C:34](=[O:36])[CH3:35])[C:30]=3[O:37]C)=[CH:28][C:23]=2[CH2:22][CH2:21]1>>[O:20]1[C:24]2[CH:25]=[CH:26][C:27]([C:29]3[S:33][CH:32]=[C:31]([C:34](=[O:36])[CH3:35])[C:30]=3[OH:37])=[CH:28][C:23]=2[CH2:22][CH2:21]1

Participants

3

Reactant 2

HCID 681611501-[5-(2,3-Dihydro-benzofuran-5-yl)-4-methoxythiophen-3-yl]ethanoneHCID 681616421-[4-Hydroxy-5-(5,6,7,8-tetrahydronaphthalen-2-yl)thiophen-3-yl]ethanone

Product 1

HCID 681612781-[5-(2,3-Dihydro-benzofuran-5-yl)-4-hydroxythiophen-3-yl]ethanoneYield 53%

Procedure

Synthesis was carried out in the same manner as in Synthesis Method 2 (6) in Reference Synthetic Example 3 by using 1.58 g (0.0058 mol) of 1-[5-(2,3-dihydro-benzofuran-5-yl)-4-methoxythiophen-3-yl]ethanone to obtain the desired product (0.8 g yield: 53%).

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-f21a4533f4c04ee5bd04804ad8a2922d
Source dataset
uspto-grants-2014_11
Patent number
US08889732B2

Reaction notes

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