Hydrochloric Acid → HCID 178528012, compound

Participants

Reaction Conditions

Reaction Steps

The crude 3-(1H-tetrazol-5-yl)aniline was mixed with dichloromethane (15 ml) and cooled to 0° C., and stirred with 2.8 ml (20 mmol) of triethylamine, 2.14 g (12 mmol) of 1,1′-thiocarbonyldiimidazole and N,N-dimethylformamide (5 mL) vigorously at 0° C. for 1 hour. Water (10 ml) was added, and concentrated hydrochloric acid was gradually added dropwise. The light brown solid precipitated at pH 6 to 7 was collected by filtration. Concentrated hydrochloric acid was gradually added dropwise, and the light brown solid precipitated at pH 5 was collected by filtration. The light brown solid was dried under reduced pressure to obtain the desired product (1.31 g, yield 64%, purity 86%).

Provenance & Evidence