関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(4-Bromo-3-nitrophenyl)ethan-1-one | HCID 87737 | — |
| 反応物 | 4-Acetylphenylboronic acid | HCID 3702122 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1,1'-(2-Nitro-[1,1'-biphenyl]-4,4'-diyl)diethanone | HCID 71272438 | — |
反応手順
1-(4-bromo-3-nitrophenyl)ethanone (2 g, 8.20 mmol) and (4-acetylphenyl)boronic acid (2.016 g, 12.29 mmol), aq.K2CO3 (2M, 12.08 mL, 24.17 mmol) and Pd(PPh3)4 (0.33 g, 0.286 mmol) were dissolved in toluene (40 mL) and heated at 110° C. for 2 days. The crude product was extracted with DCM and purified on silica gel (0-100% EtOAc/Hexane). Fractions were concentrated to give the title compound as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889726B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-5888ef84265e42a29b1c8e06e2dd6979 |
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| 出典メモ | uspto-grants-2014_11 |
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