HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (4-Benzoylbenzyl)phosphonic dichloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 4-Hydroxybenzophenone | HCID 14347 | — |
| Reactant | Methylenebis(phosphonic dichloride) | HCID 5063078 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (4-Benzoylbenzyl)phosphonic dichloride | HCID 117698973 | — |
Reaction Steps
A degradable linking agent is formed by reacting methylenebis(phosphonic dichloride) (1 eq) with 4-hydroxybenzophenone (2 eq) in anhydrous DCM using pyridine (2.5 eq) as a base. The resulting product can be converted into its salt to increase water solubility.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889760B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-c2e3305fb560461db910a7b100420e5b |
| Source note | uspto-grants-2014_11 |