HCID 23144724, compound → HCID 23144103, compound

HRID 337417Notes

Reaction equation

HRID 337417 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][CH:11]([C:14]([NH:16][C:17]3[S:18][C:19]([N:27]4[CH2:32][CH2:31][O:30][CH2:29][CH2:28]4)=[C:20]([C:22]4[O:23][CH:24]=[CH:25][CH:26]=4)[N:21]=3)=[O:15])[CH2:10][CH2:9]2)[CH:3]=1.[H][H]>C(O)C.[C].[Pd]>[O:23]1[CH:24]=[CH:25][CH:26]=[C:22]1[C:20]1[N:21]=[C:17]([NH:16][C:14]([CH:11]2[CH2:10][CH2:9][N:8]([C:4]3[CH:3]=[CH:2][N:7]=[CH:6][N:5]=3)[CH2:13][CH2:12]2)=[O:15])[S:18][C:19]=1[N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1

Participants

5

Reactant 2

HCID 23144724HCID 23144724, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23144103HCID 23144103, compoundYield 77%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Compound 51 (300 mg, 0.63 mmol) was dissolved in ethanol (10 mL), and 10% palladium-carbon (500 mg) was added thereto, followed by stirring in an atmosphere of hydrogen at room temperature for 4 hours. The reaction mixture was filtered through Celite, and the filtrate was distilled away under reduced pressure to afford the entitled Compound 52 (213 mg, 77%).

Workup

  1. filtrationThe reaction mixture was filtered through Celite
  2. distillationthe filtrate was distilled away under reduced pressure

Sources & evidence

ORD record
ord-8e639e62589c4602a8e301e0ff65904c
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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