HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 337452Generated: October 29, 2026
Isonicotinic Acid → HCID 23144337, compound
https://huagongshe.com/reaction/337452
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isonicotinic Acid | HCID 5922 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 1-Hydroxybenzotriazole hydrate | HCID 2796029 | — |
| Reactant | HCID 23144251 | HCID 23144251 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 23144337 | HCID 23144337 | 72.8% |
Reaction Steps
Compound 186 (209 mg, 0.770 mmol) was dissolved in DMF (4 mL), and isonicotinic acid (190 mg, 1.54 mmol), EDC hydrochloride (296 mg, 1.54 mmol) and 1-hydroxybenzotriazole monohydrate (236 mg, 1.54 mmol) were added thereto, followed by stirring at 50° C. for 3 hours. Water was added to the reaction mixture, and the precipitated solid was collected by filtration, followed by reslurrying with ethanol to afford the entitled Compound 187 (211 mg, 72%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08889718B2 |
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| Source dataset | uspto-grants-2014_11 |
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| ORD ID | ord-d88e6dcba87143c99c3cac0b554d2c89 |
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| Source note | uspto-grants-2014_11 |
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