HCID 23144519, compound → HCID 23144780, compound

HRID 337482Notes

Reaction equation

HRID 337482 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[S:9][C:10]=1[C:11]([C:13]#[C:14][CH2:15][O:16][CH3:17])=[O:12].[H][H]>C(O)C.[C].[Pd]>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:22])[CH3:24])[S:9][C:10]=1[C:11]([CH2:13][CH2:14][CH2:15][O:16][CH3:17])=[O:12]

Participants

5

Reactant 2

HCID 23144519HCID 23144519, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23144780HCID 23144780, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

Compound 414 (92.3 mg, 0.255 mmol) was dissolved in ethanol (5 mL), and 10% palladium-carbon (15.8 mg) was added thereto, followed by stirring in an atmosphere of hydrogen at room temperature for 1.5 hours. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to afford the entitled Compound 415 (93.3 mg, 100%).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-7f1d451b48e14d8497d78198af49ee0a
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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