Isonicotinic Acid → N-[4-(2-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]pyridine-4-carboxamide

참여 물질

역할	이름	HCID	투입량
반응물	Isonicotinic Acid	HCID 5922	—
반응물	Sodium Bicarbonate	HCID 516892	—
반응물	1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride	HCID 2723939	—
반응물	1-Hydroxybenzotriazole hydrate	HCID 2796029	—
반응물	2-Amino-4-(2-furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazole	HCID 86612468	—
용매	Water	HCID 962	—
용매	Dimethylformamide	HCID 6228	—
생성물	N-[4-(2-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]pyridine-4-carboxamide	HCID 23144697	48%

반응 조건

온도	80 °C

반응 단계

Compound 454 (6.95 g, 25.0 mmol) was dissolved in DMF (100 mL), and isonicotinic acid (36.9 g, 300 mmol), EDC hydrochloride (57.6 g, 300 mmol) and 1-hydroxybenzotriazole monohydrate (45.9 g, 300 mmol) were added thereto, followed by stirring at 80° C. for 6 hours. The reaction mixture was poured into a mixture of a saturated aqueous solution of sodium hydrogencarbonate (600 mL) and water (200 mL), and the precipitated solid was collected by filtration. The resulting solid was recrystallized from ethanol to afford the entitled Compound 455 (4.41 g, 48%) as a grayish white solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08889718B2
출처 데이터셋	uspto-grants-2014_11
ORD ID	ord-cc12686c0e4f4a17afccb2801f614477
출처 메모	uspto-grants-2014_11