Iodine → HCID 23144669, compound

HRID 337530Notes

Reaction equation

HRID 337530 reaction equation
[I:1]I.Br[C:4]1[S:8][C:7]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[N:6][C:5]=1[C:18]1[O:19][CH:20]=[CH:21][CH:22]=1>>[O:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:5]1[N:6]=[C:7]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[S:8][C:4]=1[I:1]

Participants

3

Reactant 2

HCID 807IodineHCID 23144768HCID 23144768, compound

Product 1

HCID 23144669HCID 23144669, compoundYield 56%

Procedure

In a manner similar to that in Example 92, by using iodine (26.3 g, 104 mmol) in place of DMF and using N-[5-bromo-4-(2-furyl)thiazol-2-yl]benzamide (10.3 g, 29.6 mmol) obtained in Step 1 in place of Compound h, the entitled Compound n (6.56 g, 56%) was obtained as a white solid.

Sources & evidence

ORD record
ord-12da2ae727124066b834fcc25507444c
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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