Sodium Bicarbonate → HCID 86651667, compound

Participants

Reaction Steps

To a suspension of 1,1-dimethylethyl cyclopropyl{[6-(hydroxymethyl)-8-quinolinyl]methyl}carbamate (1 eq.) from the previous step and sodium bicarbonate (1.1 eq.) in dichloromethane (0.1 M) was added DMP (1.1 eq.) at 0° C. The resulting mixture was stirred at RT for 2 h before it was quenched with sat. aq. NaHSO3 and then extracted with Et2O. The combined organic extracts were washed further with 1 N aq. NaOH, water and brine, dried over Na2SO4, and filtered. Concentration of the filtrate in vacuo afforded the crude title compound as a white solid.

Provenance & Evidence