Dichloromethane → HCID 66896394, compound

Participants

Reaction Steps

To a solution of 1,1-dimethylethyl cyclopropyl[(6-formyl-8-quinolinyl)methyl]carbamate (1 eq.) from the previous step in dichloromethane (0.06 M) was added methyl(triphenylphosphoranylidene)acetate (1.1 eq.) at 0° C. The resulting solution was then allowed to warm slowly to RT over 4 h. The volatiles were then removed in vacuo. Purification of the crude product thus obtained by way of flash chromatography (SiO2, 9:1 (v/v) Hex:EtOAc→3:7 (v/v) Hex:EtOAc) afforded the title compound as a white solid.

Provenance & Evidence