反应详情

A mixture of (3-bromo-5-iodophenyl)methanol from the previous step (1.0 eq.) and Dess-Martin periodinane (1.18 eq.) was stirred at RT in dichloromethane (0.1 M) for 45 min. The reaction mixture was diluted with ether, filtered through a plug of SiO2, and the silica washed with a 3:1 (v/v) mixture of hexanes:EtOAc. The filtrate was concentrated in vacuo and passed again through a plug of SiO2, eluting with a 3:1 (v/v) mixture of hexanes:EtOAc to afford the title compound as a light yellow solid.

1. filtrationfiltered through a plug of SiO2
2. washthe silica washed with a 3:1 (v/v) mixture of hexanes
3. concentrationThe filtrate was concentrated in vacuo
4. washeluting with a 3:1 (v/v) mixture of hexanes