HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Toluene → 4-Bromo-2-methoxypyridine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Toluene | HCID 1140 | — |
| Edukt | 4-Bromo-2-chloropyridine | HCID 3847770 | — |
| Edukt | Sodium Methoxide | HCID 10942334 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Produkt | 4-Bromo-2-methoxypyridine | HCID 14062309 | — |
Reaktionsschritte
4-Bromo-2-chloropyridine, sodium methoxide (1.6 equiv.) and toluene (6.1 volumes) were heated to 95° C. for 40 h. Toluene (6.1 volumes) and water (3 volumes) were added and the lower aqueous phase cut away. The organic was washed with water (1.5 volumes) and then the volatiles evaporated to give the title compound as an oil. HRMS (ES, M+H) Calcd 187.9711. Found 187.9711.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08889714B2 |
| Quelldatensatz | uspto-grants-2014_11 |
| ORD ID | ord-d4355942cb0447278fa4b6fa160cb7ba |
| Quellennotiz | uspto-grants-2014_11 |