HCID 131732030, compound → HCID 178472531, compound

Participants

Reaction Steps

To an ethanol solution (0.07 M) of trans-1-(1,1-dimethylethyl) 3-ethyl 4-{2,3-dimethyl-6-[(phenylmethyl)oxy]-4-pyridinyl}-1,3-piperidinedicarboxylate (1 eq.) from the previous step was added palladium (10% w/w over carbon, 0.1 eq.). The resulting suspension was evacuated and purged with hydrogen. Under a balloon-filled hydrogen atmosphere, the reaction mixture was stirred at RT for 2 h. The reaction was then quenched with CH2Cl2, filtered through a bed of celite and the insolubles rinsed with EtOAc. Concentration of the filtrate in vacuo afforded the title compound as a white solid.

Provenance & Evidence