Lithium borohydride → HCID 131732038, compound

Participants

Reaction Steps

To a THF solution (0.08 M) of trans-1,1-dimethylethyl 3-{[cyclopropyl({2,3-dichloro-5-[4-(methyloxy)-4-oxobutyl]phenyl}methyl)amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)-1-piperidinecarboxylate (1 eq.) from the previous step was added lithium borohydride (6 eq.) in one rapid portion. After 3 h, the reaction was quenched with the careful addition of 10% aq. HCl. The aqueous layer was separated and back-extracted with EtOAc. The combined organic extract were washed further with 1 N aq. NaOH, water and brine, dried over Na2SO4 and filtered. Concentration of the filtrate in vacuo afforded the title compound as a white froth.

Provenance & Evidence