Hydrochloric Acid → HCID 67062056, compound

Participants

Reaction Steps

To a CH2Cl2 solution (0.05 M) of trans-1,1-dimethylethyl 3-[(cyclopropyl{[2,3-dichloro-5-(4-hydroxybutyl)phenyl]methyl}amino]carbonyl}-4-(1-methyl-2-oxo-1,2-dihydro-4-pyridinyl)-1-piperidinecarboxylate (1 eq.) from the previous step was added HCl (4.0 M dioxane solution, 30 eq.). The resulting solution was stirred at RT for 3 h. Following the removal of the volatiles in vacuo, the resulting residue was directly loaded onto a SiO2 column packed with 93:7 (v/v) CH2Cl2:2.0 M NH3 in MeOH. Elution with the same solvent system furnished the title compound as a white froth. MS (ESI+, M+H): 508.

Provenance & Evidence