HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 89963270, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (1R)-2β-Phenylcyclohexane-1β-ol | HCID 12511044 | — |
| Reactant | N-(2,4-Dimethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide | HCID 59436583 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 89963270 | HCID 89963270 | 22.2% |
Reaction Steps
The reaction and aftertreatment were conducted in the same manner as in Example 1a by using the N-(2,4-dimethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (WO 2010/079443; 177 mg, 0.397 mmol), (1R*,2R*)-2-phenylcyclohexanol (70.0 mg, 0.397 mmol), sodium hydride (63%; 30.3 mg, 0.794 mol) and DMSO (5.0 mL), to yield the title compound (53.0 mg, 22%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889741B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-dd284c8fc4644d608ce5e2461659ea58 |
| Source note | uspto-grants-2014_11 |