HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dabco → N-(2,4-Dimethoxybenzyl)-2,3,4-trifluoro-N-(pyrimidin-4-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 2,3,4-Trifluorobenzenesulfonyl chloride | HCID 2776977 | — |
| Reactant | N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine | HCID 63362995 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | N-(2,4-Dimethoxybenzyl)-2,3,4-trifluoro-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 89962337 | 31% |
Reaction Steps
The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidine-4-amine (400 mg, 1.63 mmol) prepared in Example 14a, 2,3,4-trifluorobenzenesulfonyl chloride (752 mg, 3.26 mmol), 1,4-diazabicyclo[2.2.2]octane (366 mg, 3.26 mmol) and acetonitrile (8.0 mL), to yield the title compound (221 mg, 31%) as a colorless amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889741B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-d75f4f88f7f8429a9071b5897136daae |
| Source note | uspto-grants-2014_11 |