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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 337777Generated: October 29, 2026

Trifluoroacetic acid → HCID 89963869, compound

https://huagongshe.com/reaction/337777

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantTriethylsilaneHCID 12052—
ReactantHCID 89962072HCID 89962072—
SolventDichloromethaneHCID 6344—
ProductHCID 89963869HCID 8996386992%

Reaction Steps

The reaction and aftertreatment were conducted in the same manner as in Example 1b by using the N-(2,4-dimethoxybenzyl)-2,5-difluoro-4-{[(1S*,2R*)-2-pyridin-3-ylcyclohexyl]oxy}-N-(pyrimidin-4-yl)benzenesulfonamide (0.11 g, 0.19 mmol) prepared in Example 39c, triethylsilane (0.15 mL), trifluoroacetic acid (0.19 g) and dichloromethane (1.9 mL), to yield the title compound (77 mg, 92%) as a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889741B2
Source datasetuspto-grants-2014_11
ORD IDord-22de5858d6a649399d1f15643ee1d55e
Source noteuspto-grants-2014_11