HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dabco → N-(2,4-dimethoxybenzyl)-4-fluoro-3-methyl-N-(pyrimidin-4-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dabco | HCID 9237 | — |
| Reactant | 4-Fluoro-3-methylbenzene-1-sulfonyl chloride | HCID 2782758 | — |
| Reactant | N-(2,4-Dimethoxybenzyl)pyrimidin-4-amine | HCID 63362995 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2,4-dimethoxybenzyl)-4-fluoro-3-methyl-N-(pyrimidin-4-yl)benzenesulfonamide | HCID 89963561 | 59.7% |
Reaction Steps
The reaction and aftertreatment were conducted in the same manner as in Example 14b by using the N-(2,4-dimethoxybenzyl)pyrimidin-4-amine (590 mg, 2.40 mmol) prepared in Example 14a, 4-fluoro-3-methylbenzenesulfonyl chloride (WO 2010/079443; 1000 mg, 4.79 mmol), 1,4-diazabicyclo[2.2.2]octane (537 mg, 4.79 mmol) and THF (20 mL), to yield the title compound (598 mg, 50%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889741B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-0ddb4a4eca7b45369432428807c2a6be |
| Source note | uspto-grants-2014_11 |