HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → (1S*,2R*)-2-(3-Aminopyridazin-4-yl)cyclohexanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 2-(3-Aminopyridazin-4-yl)cyclohex-2-en-1-one | HCID 89963052 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (1S*,2R*)-2-(3-Aminopyridazin-4-yl)cyclohexanol | HCID 89962602 | 100.9% |
Reaction Steps
The reaction and aftertreatment were conducted in the same manner as in Example 72d by using the 2-(3-aminopyridazin-4-yl)cyclohex-2-en-1-one (40 mg, 0.20 mmol) prepared in Example 82d, sodium borohydride (20 mg, 0.59 mmol) and methanol (2.0 mL), to yield the title compound (39 mg, 99%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889741B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-6db95d5706bc49da8b34a4d53175fbe8 |
| Source note | uspto-grants-2014_11 |