Ethylene Glycol → 8,8-Difluoro-6-iodo-1,4-dioxaspiro[4.5]dec-6-ene

Participants

Reaction Steps

The reaction and aftertreatment were conducted in the same manner as in Example 67a by using the 4,4-difluoro-2-iodocyclohex-2-en-1-one (1.46 g, 5.66 mmol) prepared in Example 88c, ethylene glycol (750 mg, 12.1 mmol), p-toluenesulfonic acid hydrate (60 mg, 0.31 mmol) and benzene (30 mL), to yield a mixture of the title compound and a by-product.

Provenance & Evidence